NKRF_HUMAN 2019

Gene Name NKRF

Description NF-kappa-B-repressing factor

Length 690

9606

Sequence

>sp|O15226|NKRF_HUMAN NF-kappa-B-repressing factor
MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVKSSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.277

OAF_HUMAN

Out at first protein homolog

0.285

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.285

WNT1_HUMAN

Proto-oncogene Wnt-1

0.320

SPIR2_HUMAN

Protein spire homolog 2

0.320

SHRM2_HUMAN

Protein Shroom2

0.324

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.324

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.324

SPT2_HUMAN

Protein SPT2 homolog

0.329

NMBR_HUMAN

Neuromedin-B receptor

0.329

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.333

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.349

CTCF_HUMAN

Transcriptional repressor CTCF

0.354

SOCS5_HUMAN

Suppressor of cytokine signaling 5

0.358

RHG19_HUMAN

Rho GTPase-activating protein 19

0.358

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.358

XYLK_HUMAN

Glycosaminoglycan xylosylkinase

0.358

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.358

HELZ_HUMAN

Probable helicase with zinc finger domain

0.358

SSR2_HUMAN

Somatostatin receptor type 2

0.358

MMS22_HUMAN

Protein MMS22-like

0.363

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.363

SOCS2_HUMAN

Suppressor of cytokine signaling 2

0.363

SHRM3_HUMAN

Protein Shroom3

0.363

GBX2_HUMAN

Homeobox protein GBX-2

0.363

CISH_HUMAN

Cytokine-inducible SH2-containing protein

0.363

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.363

DRD5_HUMAN

D(1B) dopamine receptor

0.363

ZN503_HUMAN

Zinc finger protein 503

0.363

NCOA2_HUMAN

Nuclear receptor coactivator 2

0.368

ZN703_HUMAN

Zinc finger protein 703

0.368

METRL_HUMAN

Meteorin-like protein

0.373

PRD10_HUMAN

PR domain zinc finger protein 10

0.373

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.378

JIP1_HUMAN

C-Jun-amino-terminal kinase-interacting protein 1

0.378

ZN704_HUMAN

Zinc finger protein 704

0.378

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.383

MOSMO_HUMAN

Modulator of smoothened protein

0.383

PO2F3_HUMAN

POU domain, class 2, transcription factor 3

0.383

SYT14_HUMAN

Synaptotagmin-14

0.383

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.383

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.387

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.387

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.387

NEUL2_HUMAN

Neuralized-like protein 2

0.387

RXFP1_HUMAN

Relaxin receptor 1

0.387

GXLT2_HUMAN

Glucoside xylosyltransferase 2

0.387

TM242_HUMAN

Transmembrane protein 242

0.387

TCAIM_HUMAN

T-cell activation inhibitor, mitochondrial

0.387

OPN4_HUMAN

Melanopsin

0.387

ZN318_HUMAN

Zinc finger protein 318

0.392

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.392

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.392

RHBT1_HUMAN

Rho-related BTB domain-containing protein 1

0.392

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.392

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.392

SPIR1_HUMAN

Protein spire homolog 1

0.392

FRMD3_HUMAN

FERM domain-containing protein 3

0.392

NMUR1_HUMAN

Neuromedin-U receptor 1

0.392

NINJ1_HUMAN

Ninjurin-1

0.392

BAIP2_HUMAN

Brain-specific angiogenesis inhibitor 1-associated protein 2

0.392

GPS2_HUMAN

G protein pathway suppressor 2

0.392

TAL1_HUMAN

T-cell acute lymphocytic leukemia protein 1

0.397

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.397

BMPR2_HUMAN

Bone morphogenetic protein receptor type-2

0.397

CLOCK_HUMAN

Circadian locomoter output cycles protein kaput

0.397

CTIF_HUMAN

CBP80/20-dependent translation initiation factor

0.397

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CUED2_HUMAN

CUE domain-containing protein 2

0.335

ETV6_HUMAN

Transcription factor ETV6

0.336

HXA2_HUMAN

Homeobox protein Hox-A2

0.338

CTCF_HUMAN

Transcriptional repressor CTCF

0.341

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.345

NRF1_HUMAN

Nuclear respiratory factor 1

0.346

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.347

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.348

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.348

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.349

SPSY_HUMAN

Spermine synthase

0.357

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.359

OAF_HUMAN

Out at first protein homolog

0.360

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.361

GABPA_HUMAN

GA-binding protein alpha chain

0.362

NMBR_HUMAN

Neuromedin-B receptor

0.362

HELZ_HUMAN

Probable helicase with zinc finger domain

0.362

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.364

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.365

SMO_HUMAN

Smoothened homolog

0.366

TM35A_HUMAN

Transmembrane protein 35A

0.367

RHG19_HUMAN

Rho GTPase-activating protein 19

0.369

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.369

ZN318_HUMAN

Zinc finger protein 318

0.369

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.371

T183A_HUMAN

Transmembrane protein 183A

0.372

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.372

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.372

ZMYM2_HUMAN

Zinc finger MYM-type protein 2

0.374

TCF21_HUMAN

Transcription factor 21

0.374

XYLK_HUMAN

Glycosaminoglycan xylosylkinase

0.374

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.376

NINJ1_HUMAN

Ninjurin-1

0.377

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.377

T179A_HUMAN

Transmembrane protein 179

0.377

SPT2_HUMAN

Protein SPT2 homolog

0.378

FA13B_HUMAN

Protein FAM13B

0.378

F234B_HUMAN

Protein FAM234B

0.378

WNT1_HUMAN

Proto-oncogene Wnt-1

0.378

K0825_HUMAN

Uncharacterized protein KIAA0825

0.378

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.378

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.379

SPY4_HUMAN

Protein sprouty homolog 4

0.379

RSLAB_HUMAN

Ras-like protein family member 10B

0.379

ZN704_HUMAN

Zinc finger protein 704

0.380

INTU_HUMAN

Protein inturned

0.381

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.382

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.383

WHRN_HUMAN

Whirlin

0.383

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.383

TM242_HUMAN

Transmembrane protein 242

0.384

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.384

RXFP1_HUMAN

Relaxin receptor 1

0.384

MBD5_HUMAN

Methyl-CpG-binding domain protein 5

0.385

GBRA4_HUMAN

Gamma-aminobutyric acid receptor subunit alpha-4

0.386

SYT14_HUMAN

Synaptotagmin-14

0.387

FBX33_HUMAN

F-box only protein 33

0.388

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.388

KIBRA_HUMAN

Protein KIBRA

0.388

TDRD7_HUMAN

Tudor domain-containing protein 7

0.390

SPIR2_HUMAN

Protein spire homolog 2

0.390

TNR6C_HUMAN

Trinucleotide repeat-containing gene 6C protein

0.390

LYSC_HUMAN

Lysozyme C

0.391

REL_HUMAN

Proto-oncogene c-Rel

0.392

SMIM8_HUMAN

Small integral membrane protein 8

0.393

HMGX4_HUMAN

HMG domain-containing protein 4

0.393

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.393

GTSF1_HUMAN

Gametocyte-specific factor 1

0.393

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.393

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.393

NCOA6_HUMAN

Nuclear receptor coactivator 6

0.393

AR6P1_HUMAN

ADP-ribosylation factor-like protein 6-interacting protein 1

0.394

TSP4_HUMAN

Thrombospondin-4

0.395

CLOCK_HUMAN

Circadian locomoter output cycles protein kaput

0.395

RHBT2_HUMAN

Rho-related BTB domain-containing protein 2

0.395

GBRA1_HUMAN

Gamma-aminobutyric acid receptor subunit alpha-1

0.395

GBRA5_HUMAN

Gamma-aminobutyric acid receptor subunit alpha-5

0.395

SPY1_HUMAN

Protein sprouty homolog 1

0.395

CHRD_HUMAN

Chordin

0.397

SPIR1_HUMAN

Protein spire homolog 1

0.397

BICL1_HUMAN

BICD family-like cargo adapter 1

0.397

F107B_HUMAN

Protein FAM107B

0.398

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.398

USH1C_HUMAN

Harmonin

0.398

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.398

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.399

RREB1_HUMAN

Ras-responsive element-binding protein 1

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 36 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy