PA2G3_HUMAN 2019

Gene Name PA2G3

Description Group 3 secretory phospholipase A2

Length 509

9606

Sequence

>sp|Q9NZ20|PA2G3_HUMAN Group 3 secretory phospholipase A2
MGVQAGLFGMLGFLGVALGGSPALRWYRTSCHLTKAVPGNPLGYLSFLAKDAQGLALIHARWDAHRRLQSCSWEDEPELTAAYGALCAHETAWGSFIHTPGPELQRALATLQSQWEACRALEESPAGARKKRAAGQSGVPGGGHQREKRGWTMPGTLWCGVGDSAGNSSELGVFQGPDLCCREHDRCPQNISPLQYNYGIRNYRFHTISHCDCDTRFQQCLQNQHDSISDIVGVAFFNVLEIPCFVLEEQEACVAWYWWGGCRMYGTVPLARLQPRTFYNASWSSRATSPTPSSRSPAPPKPRQKQHLRKGPPHQKGSKRPSKANTTALQDPMVSPRLDVAPTGLQGPQGGLKPQGARWVCRSFRRHLDQCEHQIGPREIEFQLLNSAQEPLFHCNCTRRLARFLRLHSPPEVTNMLWELLGTTCFKLAPPLDCVEGKNCSRDPRAIRVSARHLRRLQQRRHQLQDKGTDERQPWPSEPLRGPMSFYNQCLQLTQAARRPDRQQKSWSQ

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.277

CTCF_HUMAN

Transcriptional repressor CTCF

0.316

CHRD_HUMAN

Chordin

0.320

SOCS5_HUMAN

Suppressor of cytokine signaling 5

0.320

OAF_HUMAN

Out at first protein homolog

0.324

ZN423_HUMAN

Zinc finger protein 423

0.324

GBX2_HUMAN

Homeobox protein GBX-2

0.324

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.324

ZN503_HUMAN

Zinc finger protein 503

0.324

MAIP1_HUMAN

m-AAA protease-interacting protein 1, mitochondrial

0.329

ZN703_HUMAN

Zinc finger protein 703

0.329

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.345

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.349

GDF11_HUMAN

Growth/differentiation factor 11

0.349

PRD13_HUMAN

PR domain zinc finger protein 13

0.349

SPIR2_HUMAN

Protein spire homolog 2

0.354

OPN4_HUMAN

Melanopsin

0.354

PDZD2_HUMAN

PDZ domain-containing protein 2

0.354

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.354

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.354

BTBDH_HUMAN

BTB/POZ domain-containing protein 17

0.354

FRMD3_HUMAN

FERM domain-containing protein 3

0.358

SHRM2_HUMAN

Protein Shroom2

0.358

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.358

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.358

GPS2_HUMAN

G protein pathway suppressor 2

0.358

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.358

NKRF_HUMAN

NF-kappa-B-repressing factor

0.358

NINJ1_HUMAN

Ninjurin-1

0.358

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.363

TAL1_HUMAN

T-cell acute lymphocytic leukemia protein 1

0.363

RASD1_HUMAN

Dexamethasone-induced Ras-related protein 1

0.363

NMBR_HUMAN

Neuromedin-B receptor

0.363

PHC2_HUMAN

Polyhomeotic-like protein 2

0.374

NEGR1_HUMAN

Neuronal growth regulator 1

0.378

NRF1_HUMAN

Nuclear respiratory factor 1

0.378

HXA1_HUMAN

Homeobox protein Hox-A1

0.378

STRAA_HUMAN

STE20-related kinase adapter protein alpha

0.378

EVX1_HUMAN

Homeobox even-skipped homolog protein 1

0.378

GAB2_HUMAN

GRB2-associated-binding protein 2

0.378

JIP2_HUMAN

C-Jun-amino-terminal kinase-interacting protein 2

0.378

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.383

IGLO5_HUMAN

IgLON family member 5

0.383

SCHI1_HUMAN

Schwannomin-interacting protein 1

0.383

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.383

NCAM2_HUMAN

Neural cell adhesion molecule 2

0.383

SPRC_HUMAN

SPARC

0.383

GDF8_HUMAN

Growth/differentiation factor 8

0.383

AMRP_HUMAN

Alpha-2-macroglobulin receptor-associated protein

0.383

HMGX4_HUMAN

HMG domain-containing protein 4

0.383

SMO_HUMAN

Smoothened homolog

0.383

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.387

RHG19_HUMAN

Rho GTPase-activating protein 19

0.387

FA43B_HUMAN

Protein FAM43B

0.387

ZEP2_HUMAN

Transcription factor HIVEP2

0.387

ZEP1_HUMAN

Zinc finger protein 40

0.387

HOIL1_HUMAN

RanBP-type and C3HC4-type zinc finger-containing protein 1

0.387

CP110_HUMAN

Centriolar coiled-coil protein of 110 kDa

0.387

IQIP1_HUMAN

IQCJ-SCHIP1 readthrough transcript protein

0.387

FA43A_HUMAN

Protein FAM43A

0.387

SSR2_HUMAN

Somatostatin receptor type 2

0.387

NKX32_HUMAN

Homeobox protein Nkx-3.2

0.387

ZN384_HUMAN

Zinc finger protein 384

0.392

SHRM3_HUMAN

Protein Shroom3

0.392

OSER1_HUMAN

Oxidative stress-responsive serine-rich protein 1

0.392

RSLAB_HUMAN

Ras-like protein family member 10B

0.392

UBL7_HUMAN

Ubiquitin-like protein 7

0.392

PTK7_HUMAN

Inactive tyrosine-protein kinase 7

0.392

DRD5_HUMAN

D(1B) dopamine receptor

0.392

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.392

A0A2R8Y872_HUMAN

Putative ATP-dependent RNA helicase TDRD12

0.392

BOK_HUMAN

Bcl-2-related ovarian killer protein

0.392

T183A_HUMAN

Transmembrane protein 183A

0.397

NCOA2_HUMAN

Nuclear receptor coactivator 2

0.397

ZN609_HUMAN

Zinc finger protein 609

0.399

DAG1_HUMAN

Dystroglycan

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

CTCF_HUMAN

Transcriptional repressor CTCF

0.321

NRF1_HUMAN

Nuclear respiratory factor 1

0.326

ETV6_HUMAN

Transcription factor ETV6

0.333

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.334

RSLAB_HUMAN

Ras-like protein family member 10B

0.344

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.345

SYT14_HUMAN

Synaptotagmin-14

0.354

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.358

NINJ1_HUMAN

Ninjurin-1

0.358

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.359

NMBR_HUMAN

Neuromedin-B receptor

0.359

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.361

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.361

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.361

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.362

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.364

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.365

RHG19_HUMAN

Rho GTPase-activating protein 19

0.365

CUED2_HUMAN

CUE domain-containing protein 2

0.365

HXA2_HUMAN

Homeobox protein Hox-A2

0.367

NKRF_HUMAN

NF-kappa-B-repressing factor

0.369

KIBRA_HUMAN

Protein KIBRA

0.370

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.371

PHC2_HUMAN

Polyhomeotic-like protein 2

0.371

OAF_HUMAN

Out at first protein homolog

0.372

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.372

T179A_HUMAN

Transmembrane protein 179

0.373

REL_HUMAN

Proto-oncogene c-Rel

0.373

ZN503_HUMAN

Zinc finger protein 503

0.376

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.377

SMO_HUMAN

Smoothened homolog

0.378

INTU_HUMAN

Protein inturned

0.378

CHRD_HUMAN

Chordin

0.379

SPIR1_HUMAN

Protein spire homolog 1

0.379

USH1C_HUMAN

Harmonin

0.380

SPRE2_HUMAN

Sprouty-related, EVH1 domain-containing protein 2

0.381

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.381

USH1G_HUMAN

Usher syndrome type-1G protein

0.383

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.383

T183A_HUMAN

Transmembrane protein 183A

0.384

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.384

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.385

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.385

CRHBP_HUMAN

Corticotropin-releasing factor-binding protein

0.385

TCF21_HUMAN

Transcription factor 21

0.386

YAP1_HUMAN

Transcriptional coactivator YAP1

0.387

GABPA_HUMAN

GA-binding protein alpha chain

0.388

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.388

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.388

SAPC2_HUMAN

Suppressor APC domain-containing protein 2

0.388

CP110_HUMAN

Centriolar coiled-coil protein of 110 kDa

0.389

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.389

HMGX4_HUMAN

HMG domain-containing protein 4

0.390

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.390

AXIN2_HUMAN

Axin-2

0.390

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.390

TSP4_HUMAN

Thrombospondin-4

0.391

CLOCK_HUMAN

Circadian locomoter output cycles protein kaput

0.391

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.392

TF65_HUMAN

Transcription factor p65

0.392

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.393

OPN4_HUMAN

Melanopsin

0.393

TM35A_HUMAN

Transmembrane protein 35A

0.393

WHRN_HUMAN

Whirlin

0.393

BICL1_HUMAN

BICD family-like cargo adapter 1

0.394

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.395

ZN318_HUMAN

Zinc finger protein 318

0.395

ZN609_HUMAN

Zinc finger protein 609

0.395

CRERF_HUMAN

CREB3 regulatory factor

0.396

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.396

SPSY_HUMAN

Spermine synthase

0.397

ZMYM2_HUMAN

Zinc finger MYM-type protein 2

0.400

PTN21_HUMAN

Tyrosine-protein phosphatase non-receptor type 21

0.400

AXIN1_HUMAN

Axin-1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 37 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy