ID2_HUMAN 2019

Gene Name ID2

Description DNA-binding protein inhibitor ID-2

Length 134

9606

Sequence

>sp|Q02363|ID2_HUMAN DNA-binding protein inhibitor ID-2
MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.316

KI26B_HUMAN

Kinesin-like protein KIF26B

0.349

BICL1_HUMAN

BICD family-like cargo adapter 1

0.349

RFX7_HUMAN

DNA-binding protein RFX7

0.358

OAF_HUMAN

Out at first protein homolog

0.363

ZN503_HUMAN

Zinc finger protein 503

0.363

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.363

AXIN2_HUMAN

Axin-2

0.378

OTOP1_HUMAN

Proton channel OTOP1

0.383

LHPL2_HUMAN

LHFPL tetraspan subfamily member 2 protein

0.387

TM242_HUMAN

Transmembrane protein 242

0.387

OTOP2_HUMAN

Proton channel OTOP2

0.387

NEUL2_HUMAN

Neuralized-like protein 2

0.387

OPN4_HUMAN

Melanopsin

0.387

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.387

TCF21_HUMAN

Transcription factor 21

0.387

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.392

SHRM2_HUMAN

Protein Shroom2

0.392

NKRF_HUMAN

NF-kappa-B-repressing factor

0.392

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.392

NINJ1_HUMAN

Ninjurin-1

0.392

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.397

PRDM8_HUMAN

PR domain zinc finger protein 8

0.397

CTIF_HUMAN

CBP80/20-dependent translation initiation factor

0.397

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.397

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

ID3_HUMAN

DNA-binding protein inhibitor ID-3

0.289

TCF21_HUMAN

Transcription factor 21

0.322

ETV6_HUMAN

Transcription factor ETV6

0.333

BICL1_HUMAN

BICD family-like cargo adapter 1

0.334

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.337

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.345

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.345

CHRD_HUMAN

Chordin

0.348

CTCF_HUMAN

Transcriptional repressor CTCF

0.355

OAF_HUMAN

Out at first protein homolog

0.357

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.357

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.358

NRF1_HUMAN

Nuclear respiratory factor 1

0.359

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.360

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.361

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.361

BCAP_HUMAN

Phosphoinositide 3-kinase adapter protein 1

0.361

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.362

INTU_HUMAN

Protein inturned

0.363

TM35A_HUMAN

Transmembrane protein 35A

0.364

USH1C_HUMAN

Harmonin

0.365

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.366

T183A_HUMAN

Transmembrane protein 183A

0.369

VGLL2_HUMAN

Transcription cofactor vestigial-like protein 2

0.369

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.370

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.371

PHC2_HUMAN

Polyhomeotic-like protein 2

0.371

AXIN1_HUMAN

Axin-1

0.372

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.373

NINJ1_HUMAN

Ninjurin-1

0.373

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.373

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.374

SPT2_HUMAN

Protein SPT2 homolog

0.374

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.376

GTSF1_HUMAN

Gametocyte-specific factor 1

0.376

HMGX4_HUMAN

HMG domain-containing protein 4

0.376

ZN704_HUMAN

Zinc finger protein 704

0.377

SMO_HUMAN

Smoothened homolog

0.378

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.379

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.380

CCD43_HUMAN

Coiled-coil domain-containing protein 43

0.380

CUED2_HUMAN

CUE domain-containing protein 2

0.380

FST_HUMAN

Follistatin

0.381

CRERF_HUMAN

CREB3 regulatory factor

0.382

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.383

SYT14_HUMAN

Synaptotagmin-14

0.383

ID1_HUMAN

DNA-binding protein inhibitor ID-1

0.384

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.385

KIBRA_HUMAN

Protein KIBRA

0.385

CRHBP_HUMAN

Corticotropin-releasing factor-binding protein

0.385

MERL_HUMAN

Merlin

0.387

GABPA_HUMAN

GA-binding protein alpha chain

0.388

TWSG1_HUMAN

Twisted gastrulation protein homolog 1

0.388

T179A_HUMAN

Transmembrane protein 179

0.388

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.389

NMBR_HUMAN

Neuromedin-B receptor

0.389

HELZ_HUMAN

Probable helicase with zinc finger domain

0.389

MSL2_HUMAN

E3 ubiquitin-protein ligase MSL2

0.389

AXIN2_HUMAN

Axin-2

0.390

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.390

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.390

ZN503_HUMAN

Zinc finger protein 503

0.390

RSLAB_HUMAN

Ras-like protein family member 10B

0.390

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.391

CIDEC_HUMAN

Cell death activator CIDE-3

0.392

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.392

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.392

OPN4_HUMAN

Melanopsin

0.393

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.393

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.393

SPIR1_HUMAN

Protein spire homolog 1

0.393

AEBP2_HUMAN

Zinc finger protein AEBP2

0.394

F107B_HUMAN

Protein FAM107B

0.394

TM242_HUMAN

Transmembrane protein 242

0.395

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.395

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.395

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.395

ZN609_HUMAN

Zinc finger protein 609

0.395

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.396

DTBP1_HUMAN

Dysbindin

0.396

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.396

HOME1_HUMAN

Homer protein homolog 1

0.397

USH1G_HUMAN

Usher syndrome type-1G protein

0.397

SUFU_HUMAN

Suppressor of fused homolog

0.397

GP155_HUMAN

Integral membrane protein GPR155

0.398

NKRF_HUMAN

NF-kappa-B-repressing factor

0.398

SHRM2_HUMAN

Protein Shroom2

0.398

NEUL2_HUMAN

Neuralized-like protein 2

0.399

ZCH18_HUMAN

Zinc finger CCCH domain-containing protein 18

0.399

ZMYM2_HUMAN

Zinc finger MYM-type protein 2

0.400

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.400

YAP1_HUMAN

Transcriptional coactivator YAP1

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 35 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy