OPN4_HUMAN 2019

Gene Name OPN4

Description Melanopsin

Length 478

9606

Sequence

>sp|Q9UHM6|OPN4_HUMAN Melanopsin
MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKAPPRPQGHEAETPGKTKGLIPSQDPRM

Domains

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What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

EGFLA_HUMAN

Pikachurin

0.316

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.316

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.320

NINJ1_HUMAN

Ninjurin-1

0.320

SCHI1_HUMAN

Schwannomin-interacting protein 1

0.349

NKX32_HUMAN

Homeobox protein Nkx-3.2

0.354

SSR2_HUMAN

Somatostatin receptor type 2

0.354

RFX7_HUMAN

DNA-binding protein RFX7

0.354

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.354

IQIP1_HUMAN

IQCJ-SCHIP1 readthrough transcript protein

0.354

RHG19_HUMAN

Rho GTPase-activating protein 19

0.354

OAF_HUMAN

Out at first protein homolog

0.358

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.358

OSER1_HUMAN

Oxidative stress-responsive serine-rich protein 1

0.358

GBX2_HUMAN

Homeobox protein GBX-2

0.358

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.358

HAND2_HUMAN

Heart- and neural crest derivatives-expressed protein 2

0.374

ZN704_HUMAN

Zinc finger protein 704

0.374

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.374

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.378

PRD16_HUMAN

Histone-lysine N-methyltransferase PRDM16

0.378

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.378

OTOP1_HUMAN

Proton channel OTOP1

0.378

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.378

TCF21_HUMAN

Transcription factor 21

0.383

SPIR2_HUMAN

Protein spire homolog 2

0.383

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.383

4ET_HUMAN

Eukaryotic translation initiation factor 4E transporter

0.383

FRMD5_HUMAN

FERM domain-containing protein 5

0.383

NEUL2_HUMAN

Neuralized-like protein 2

0.383

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.383

AMNLS_HUMAN

Protein amnionless

0.387

MED29_HUMAN

Mediator of RNA polymerase II transcription subunit 29

0.387

INHBA_HUMAN

Inhibin beta A chain

0.387

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.387

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.387

NKRF_HUMAN

NF-kappa-B-repressing factor

0.387

TMED6_HUMAN

Transmembrane emp24 domain-containing protein 6

0.387

FRMD3_HUMAN

FERM domain-containing protein 3

0.387

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.387

GPS2_HUMAN

G protein pathway suppressor 2

0.387

VGLL4_HUMAN

Transcription cofactor vestigial-like protein 4

0.392

NMBR_HUMAN

Neuromedin-B receptor

0.392

TAL1_HUMAN

T-cell acute lymphocytic leukemia protein 1

0.392

PRDM8_HUMAN

PR domain zinc finger protein 8

0.392

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.397

PHC2_HUMAN

Polyhomeotic-like protein 2

0.399

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

NRF1_HUMAN

Nuclear respiratory factor 1

0.328

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.330

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.351

TDRKH_HUMAN

Tudor and KH domain-containing protein

0.357

OAF_HUMAN

Out at first protein homolog

0.357

NF2L1_HUMAN

Endoplasmic reticulum membrane sensor NFE2L1

0.360

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.360

RHG19_HUMAN

Rho GTPase-activating protein 19

0.365

ETV6_HUMAN

Transcription factor ETV6

0.366

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.368

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.369

CTCF_HUMAN

Transcriptional repressor CTCF

0.369

TCF21_HUMAN

Transcription factor 21

0.370

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.370

PHC2_HUMAN

Polyhomeotic-like protein 2

0.371

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.372

ENOX1_HUMAN

Ecto-NOX disulfide-thiol exchanger 1

0.372

CDR2_HUMAN

Cerebellar degeneration-related protein 2

0.372

NINJ1_HUMAN

Ninjurin-1

0.372

GABPA_HUMAN

GA-binding protein alpha chain

0.373

UBP1_HUMAN

Ubiquitin carboxyl-terminal hydrolase 1

0.374

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.375

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.375

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.376

SMO_HUMAN

Smoothened homolog

0.377

RM30_HUMAN

39S ribosomal protein L30, mitochondrial

0.377

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.378

BICL1_HUMAN

BICD family-like cargo adapter 1

0.379

BD1L1_HUMAN

Biorientation of chromosomes in cell division protein 1-like 1

0.379

NFAT5_HUMAN

Nuclear factor of activated T-cells 5

0.380

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.381

CRERF_HUMAN

CREB3 regulatory factor

0.381

USH1G_HUMAN

Usher syndrome type-1G protein

0.382

NEUL2_HUMAN

Neuralized-like protein 2

0.383

CRHBP_HUMAN

Corticotropin-releasing factor-binding protein

0.383

NMBR_HUMAN

Neuromedin-B receptor

0.388

GTSF1_HUMAN

Gametocyte-specific factor 1

0.388

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.388

CHSTB_HUMAN

Carbohydrate sulfotransferase 11

0.388

DFFB_HUMAN

DNA fragmentation factor subunit beta

0.389

CDR2L_HUMAN

Cerebellar degeneration-related protein 2-like

0.389

TSP4_HUMAN

Thrombospondin-4

0.389

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.389

ZN704_HUMAN

Zinc finger protein 704

0.389

HEY1_HUMAN

Hairy/enhancer-of-split related with YRPW motif protein 1

0.390

CIDEC_HUMAN

Cell death activator CIDE-3

0.390

INTU_HUMAN

Protein inturned

0.391

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.391

OTOP1_HUMAN

Proton channel OTOP1

0.391

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.392

TM35A_HUMAN

Transmembrane protein 35A

0.392

CHRD_HUMAN

Chordin

0.392

WHRN_HUMAN

Whirlin

0.392

SPIR1_HUMAN

Protein spire homolog 1

0.392

AEBP2_HUMAN

Zinc finger protein AEBP2

0.392

PA2G3_HUMAN

Group 3 secretory phospholipase A2

0.393

BOD1_HUMAN

Biorientation of chromosomes in cell division protein 1

0.393

ID2_HUMAN

DNA-binding protein inhibitor ID-2

0.393

CUED2_HUMAN

CUE domain-containing protein 2

0.393

USH1C_HUMAN

Harmonin

0.393

TET2_HUMAN

Methylcytosine dioxygenase TET2

0.393

NDUF4_HUMAN

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

0.394

HOME1_HUMAN

Homer protein homolog 1

0.395

SPSY_HUMAN

Spermine synthase

0.396

TIDC1_HUMAN

Complex I assembly factor TIMMDC1, mitochondrial

0.396

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.396

WFS1_HUMAN

Wolframin

0.396

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.397

SSR2_HUMAN

Somatostatin receptor type 2

0.398

RECK_HUMAN

Reversion-inducing cysteine-rich protein with Kazal motifs

0.398

AXIN1_HUMAN

Axin-1

0.398

SPIR2_HUMAN

Protein spire homolog 2

0.399

TUTLB_HUMAN

Protein turtle homolog B

0.399

ZCHC2_HUMAN

Zinc finger CCHC domain-containing protein 2

0.400

TET3_HUMAN

Methylcytosine dioxygenase TET3

0.400

T179A_HUMAN

Transmembrane protein 179

0.400

REL_HUMAN

Proto-oncogene c-Rel

0.400

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 38 organisms (of 162)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy