HOME2_HUMAN 2019

Gene Name HOME2

Description Homer protein homolog 2

Length 354

9606

Sequence

>sp|Q9NSB8|HOME2_HUMAN Homer protein homolog 2
MGEQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKLGTDN

Domains

Loading...

Help

What is the source the Gene Ontology annotation?

The Gene Ontology annotations are retrieved from the EBI's QuickGO webservice. Further informations are available in the external data sources section

What is the quality of these annotations?

For now, all GO term annotations, regardless of their evidence code, are displayed. No quality filter are used to provide the widest possible range of annotations. You can check the labels near each annotation for evidence details: manually reviewed annotations are displayed in blue, while the automatic ones are in grey.

Help

What is the source the domain annotation?

The domain annotations are dynamically queried from the Interpro database, using EBI webservice.

The source of these annotations is represented by a color code (see legend). You can access the corresponding Uniprot entries in Interpro by clicking on the synthetic representation of each domain.

Help

What are the distances?

The distances shown here are Jaccard distances, which are adapted to binary profiles (presence/absence).

How are they computed?

Distances between two protein of a given species are computed on phylogenetic profile of each protein in model species of the considered database.

Threshold

The goal of this section is to provide proteins with similar distributions to the query, to that end, we set a maximum threshold at 0.4

Proteins with similar distribution in the three Life domains

Identifier

Description

Distance between phylogenetic profiles

HOME1_HUMAN

Homer protein homolog 1

0.313

ARRB1_HUMAN

Beta-arrestin-1

0.357

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.360

ECSIT_HUMAN

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

0.360

ARFP1_HUMAN

Arfaptin-1

0.360

HOME3_HUMAN

Homer protein homolog 3

0.370

SKI_HUMAN

Ski oncogene

0.370

UBR5_HUMAN

E3 ubiquitin-protein ligase UBR5

0.385

ARRB2_HUMAN

Beta-arrestin-2

0.385

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.389

CREL2_HUMAN

Cysteine-rich with EGF-like domain protein 2

0.389

INSR_HUMAN

Insulin receptor

0.389

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.392

P73_HUMAN

Tumor protein p73

0.392

Proteins with similar distribution in Eukaryota

Identifier

Description

Distance between phylogenetic profiles

HOME1_HUMAN

Homer protein homolog 1

0.236

MED1_HUMAN

Mediator of RNA polymerase II transcription subunit 1

0.293

TMM11_HUMAN

Transmembrane protein 11, mitochondrial

0.306

HOME3_HUMAN

Homer protein homolog 3

0.309

PHC2_HUMAN

Polyhomeotic-like protein 2

0.314

AXIN1_HUMAN

Axin-1

0.315

GABPA_HUMAN

GA-binding protein alpha chain

0.316

NRF1_HUMAN

Nuclear respiratory factor 1

0.332

AEBP2_HUMAN

Zinc finger protein AEBP2

0.340

DLP1_HUMAN

Decaprenyl-diphosphate synthase subunit 2

0.340

FGOP2_HUMAN

FGFR1 oncogene partner 2

0.346

FSCN2_HUMAN

Fascin-2

0.350

KANL1_HUMAN

KAT8 regulatory NSL complex subunit 1

0.350

HMGX4_HUMAN

HMG domain-containing protein 4

0.350

SYTL4_HUMAN

Synaptotagmin-like protein 4

0.350

DSCL1_HUMAN

Down syndrome cell adhesion molecule-like protein 1

0.350

BICL1_HUMAN

BICD family-like cargo adapter 1

0.355

CRERF_HUMAN

CREB3 regulatory factor

0.356

FRITZ_HUMAN

WD repeat-containing and planar cell polarity effector protein fritz homolog

0.356

SUFU_HUMAN

Suppressor of fused homolog

0.357

SPSY_HUMAN

Spermine synthase

0.357

SYTL5_HUMAN

Synaptotagmin-like protein 5

0.357

GP155_HUMAN

Integral membrane protein GPR155

0.359

PHC1_HUMAN

Polyhomeotic-like protein 1

0.362

SNAI2_HUMAN

Zinc finger protein SNAI2

0.363

G2E3_HUMAN

G2/M phase-specific E3 ubiquitin-protein ligase

0.363

DCA10_HUMAN

DDB1- and CUL4-associated factor 10

0.364

ASXL2_HUMAN

Putative Polycomb group protein ASXL2

0.364

RM30_HUMAN

39S ribosomal protein L30, mitochondrial

0.367

HEY1_HUMAN

Hairy/enhancer-of-split related with YRPW motif protein 1

0.367

MYD88_HUMAN

Myeloid differentiation primary response protein MyD88

0.367

RHPN2_HUMAN

Rhophilin-2

0.369

P73_HUMAN

Tumor protein p73

0.369

ZN609_HUMAN

Zinc finger protein 609

0.370

ATP5J_HUMAN

ATP synthase-coupling factor 6, mitochondrial

0.371

41_HUMAN

Protein 4.1

0.371

CASP7_HUMAN

Caspase-7

0.371

GCM2_HUMAN

Chorion-specific transcription factor GCMb

0.372

SYT14_HUMAN

Synaptotagmin-14

0.372

USH1G_HUMAN

Usher syndrome type-1G protein

0.372

CASZ1_HUMAN

Zinc finger protein castor homolog 1

0.373

CNTN2_HUMAN

Contactin-2

0.373

SP130_HUMAN

Histone deacetylase complex subunit SAP130

0.374

MERL_HUMAN

Merlin

0.375

NF2L1_HUMAN

Endoplasmic reticulum membrane sensor NFE2L1

0.377

MTP_HUMAN

Microsomal triglyceride transfer protein large subunit

0.378

CYTSA_HUMAN

Cytospin-A

0.378

AXIN2_HUMAN

Axin-2

0.378

CASP3_HUMAN

Caspase-3

0.378

RWDD4_HUMAN

RWD domain-containing protein 4

0.379

TSP4_HUMAN

Thrombospondin-4

0.379

ZN704_HUMAN

Zinc finger protein 704

0.379

ZMYM4_HUMAN

Zinc finger MYM-type protein 4

0.379

AREL1_HUMAN

Apoptosis-resistant E3 ubiquitin protein ligase 1

0.379

P63_HUMAN

Tumor protein 63

0.382

ASXL1_HUMAN

Putative Polycomb group protein ASXL1

0.382

FSCN1_HUMAN

Fascin

0.385

LOXL2_HUMAN

Lysyl oxidase homolog 2

0.386

CRBL2_HUMAN

cAMP-responsive element-binding protein-like 2

0.386

CYTSB_HUMAN

Cytospin-B

0.386

TBK1_HUMAN

Serine/threonine-protein kinase TBK1

0.387

TCF21_HUMAN

Transcription factor 21

0.387

SMAD4_HUMAN

Mothers against decapentaplegic homolog 4

0.389

GRPR_HUMAN

Gastrin-releasing peptide receptor

0.389

TBC30_HUMAN

TBC1 domain family member 30

0.391

GPM6A_HUMAN

Neuronal membrane glycoprotein M6-a

0.391

MED28_HUMAN

Mediator of RNA polymerase II transcription subunit 28

0.391

E41L3_HUMAN

Band 4.1-like protein 3

0.392

MED30_HUMAN

Mediator of RNA polymerase II transcription subunit 30

0.392

PHC3_HUMAN

Polyhomeotic-like protein 3

0.393

KANL2_HUMAN

KAT8 regulatory NSL complex subunit 2

0.393

INTU_HUMAN

Protein inturned

0.393

MED15_HUMAN

Mediator of RNA polymerase II transcription subunit 15

0.393

NF2L2_HUMAN

Nuclear factor erythroid 2-related factor 2

0.394

TDRD9_HUMAN

ATP-dependent RNA helicase TDRD9

0.394

WHRN_HUMAN

Whirlin

0.394

DSCAM_HUMAN

Down syndrome cell adhesion molecule

0.394

SPIR1_HUMAN

Protein spire homolog 1

0.394

TM35A_HUMAN

Transmembrane protein 35A

0.394

DIK2A_HUMAN

Divergent protein kinase domain 2A

0.396

RXFP1_HUMAN

Relaxin receptor 1

0.396

CC28A_HUMAN

Coiled-coil domain-containing protein 28A

0.397

LLR1_HUMAN

Leucine-rich repeat protein 1

0.397

BTBDA_HUMAN

BTB/POZ domain-containing protein 10

0.397

E41L2_HUMAN

Band 4.1-like protein 2

0.398

CTCF_HUMAN

Transcriptional repressor CTCF

0.399

BTK_HUMAN

Tyrosine-protein kinase BTK

0.399

BAG4_HUMAN

BAG family molecular chaperone regulator 4

0.399

Orthologs and taxonomic distribution

Eukaryota: Model Organisms
Eukaryota: Whole domain
Three domains

Orthologs found in 176 organisms (of 929)

Taxonomic distribution summary

Help

This section gives an overview of the taxonomic distribution of orthologs in representative clades. Clade names correspond to NCBI taxonomy or to the accepted consensus. Classification of each species into clade is available here

Legend:

Heatmap

Each labelled tile corresponds to a clade and is colored according to the proportion of species in the clade with at least one ortholog using the following scale:

25%

50%

75%

100%

Hover on the heatmap to see the total number of species in which orthologs were found.

Tiles framed in blue indicate the clade for which a 'focused' view is available, you can click the tile to reveal it

Labels

Label colors correspond to one of three domains of Life

Eukaryota

Archaea

Bacteria

Inparalogs

When inparalogs (genes in query species resulting from a duplication event posterior to the speciation with target species) are detected, they can be displayed under the 'See Inparalogs' button. A indicates that this protein is a predicted inparalog to the query protein, relatively to (at least) one species of this clade.

Not found in

The 'Not found in' button offers the list of species in which orthologs where not found, ordered clade by clade

See inparalogs

Orthologs not found in

	Relationship type	Query & inparalogs	Orthologs	Orthologs length	Species	Taxid		Taxonomy	Whole Taxonomy